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For Y2H assays, the plasmids of pGADT7 (empty vector) or pGADT7 derivatives were introduced into the yeast strain AH109 with plasmids of pGBKT7 (empty vector) or pGBKT7 derivatives

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Additionally, the enriched KEGG pathways based on the aforementioned core target genes mainly included neutrophil extracellular trap formation, HIF-1 signaling pathway, longevity regulating pathway, p53 signaling pathway (Fig